Capsid-Modified Adenoviral Vectors for Improved Muscle-Directed Gene Therapy

Skeletal muscle represents an attractive target tissue for adenoviral gene therapy to treat muscle disorders and as a production platform for systemic expression of therapeutic proteins. However, adenovirus serotype 5 vectors do not efficiently transduce adult muscle tissue. Here we evaluated whethe...

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Autors principals: Guse, Kilian, Suzuki, Masataka, Sule, Gautam, Bertin, Terry K., Tyynismaa, Henna, Ahola-Erkkilä, Sofia, Palmer, Donna, Suomalainen, Anu, Ng, Philip, Cerullo, Vincenzo, Hemminki, Akseli, Lee, Brendan
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2012
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472516/
https://ncbi.nlm.nih.gov/pubmed/22888960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.003
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