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Cytokine-Conditioned Dendritic Cells Induce Humoral Tolerance to Protein Therapy in Mice

A major obstacle in the genetic therapy of inherited metabolic disease is host immune responses to the therapeutic protein. This is best exemplified by inhibitor formation in the protein therapy for hemophilia A. An approach to overcoming this is induction of immunological tolerance to the therapeut...

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Detalhes bibliográficos
Main Authors: Sule, Gautam, Suzuki, Masataka, Guse, Kilian, Cela, Racel, Rodgers, John R., Lee, Brendan
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404424/
https://ncbi.nlm.nih.gov/pubmed/22468961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2011.225
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