Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells

EZH2 (enhancer of zeste homolog 2) is the catalytic subunit of PRC2 (polycomb repressive complex 2), which mediates histone methyltransferase activity and functions as transcriptional repressor involved in gene silencing. EZH2 is involved in malignant transformation and biological aggressiveness of...

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Détails bibliographiques
Auteurs principaux: Kikuchi, Junko, Takashina, Taichi, Kinoshita, Ichiro, Kikuchi, Eiki, Shimizu, Yasushi, Sakakibara-Konishi, Jun, Oizumi, Satoshi, Marquez, Victor E., Nishimura, Masaharu, Dosaka-Akita, Hirotoshi
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472089/
https://ncbi.nlm.nih.gov/pubmed/22925699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2012.08.003
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