Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells

EZH2 (enhancer of zeste homolog 2) is the catalytic subunit of PRC2 (polycomb repressive complex 2), which mediates histone methyltransferase activity and functions as transcriptional repressor involved in gene silencing. EZH2 is involved in malignant transformation and biological aggressiveness of...

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Autors principals: Kikuchi, Junko, Takashina, Taichi, Kinoshita, Ichiro, Kikuchi, Eiki, Shimizu, Yasushi, Sakakibara-Konishi, Jun, Oizumi, Satoshi, Marquez, Victor E., Nishimura, Masaharu, Dosaka-Akita, Hirotoshi
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472089/
https://ncbi.nlm.nih.gov/pubmed/22925699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2012.08.003
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