Polymorphism rs11085226 in the Gene Encoding Polypyrimidine Tract-Binding Protein 1 Negatively Affects Glucose-Stimulated Insulin Secretion

OBJECTIVE: Polypyrimidine tract-binding protein 1 (PTBP1) promotes stability and translation of mRNAs coding for insulin secretion granule proteins and thereby plays a role in β-cells function. We studied whether common genetic variations within the PTBP1 locus influence insulin secretion, and/or pr...

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Bibliographische Detailangaben
Hauptverfasser: Heni, Martin, Ketterer, Caroline, Wagner, Robert, Linder, Katarzyna, Böhm, Anja, Herzberg-Schäfer, Silke A., Machicao, Fausto, Knoch, Klaus-Peter, Fritsche, Andreas, Staiger, Harald, Häring, Hans-Ulrich, Solimena, Michele
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471934/
https://ncbi.nlm.nih.gov/pubmed/23077502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046154
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