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Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin

In prostanoid biosynthesis, the first two steps are catalyzed by cyclooxygenases (COX). In mice and humans, deregulated expression of COX-2, but not of COX-1, is characteristic of epithelial tumors, including squamous cell carcinomas of skin. To explore the function of COX-2 in epidermis, a keratin...

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Autori principali: Neufang, Gitta, Fürstenberger, Gerhard, Heidt, Markus, Marks, Friedrich, Müller-Decker, Karin
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC34719/
https://ncbi.nlm.nih.gov/pubmed/11381142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.121574098
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