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Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin
In prostanoid biosynthesis, the first two steps are catalyzed by cyclooxygenases (COX). In mice and humans, deregulated expression of COX-2, but not of COX-1, is characteristic of epithelial tumors, including squamous cell carcinomas of skin. To explore the function of COX-2 in epidermis, a keratin...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC34719/ https://ncbi.nlm.nih.gov/pubmed/11381142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.121574098 |
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