Conditional Astroglial Rictor Overexpression Induces Malignant Glioma in Mice

BACKGROUND: Hyperactivation of the mTORC2 signaling pathway has been shown to contribute to the oncogenic properties of gliomas. Moreover, overexpression of the mTORC2 regulatory subunit Rictor has been associated with increased proliferation and invasive character of these tumor cells. METHODOLOGY/...

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Main Authors: Bashir, Tariq, Cloninger, Cheri, Artinian, Nicholas, Anderson, Lauren, Bernath, Andrew, Holmes, Brent, Benavides-Serrato, Angelica, Sabha, Nesrin, Nishimura, Robert N., Guha, Abhijit, Gera, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471885/
https://ncbi.nlm.nih.gov/pubmed/23077666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047741
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