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Role of Cysteine Residues in Heme Binding to Human Heme Oxygenase-2 Elucidated by Two-dimensional NMR Spectroscopy

Human heme oxygenases 1 and 2 (HO-1 and HO-2) degrade heme in the presence of oxygen and NADPH-cytochrome P450 reductase, producing ferrous iron, CO, and biliverdin. HO-1 is an inducible enzyme, but HO-2 is constitutively expressed in selected tissues and is involved in signaling and regulatory proc...

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Bibliografiske detaljer
Main Authors: Varfaj, Fatbardha, Lampe, Jed N., Ortiz de Montellano, Paul R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471713/
https://ncbi.nlm.nih.gov/pubmed/22923613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.378042
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