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Isocyanides Inhibit Human Heme Oxygenases at the Verdoheme Stage
Heme oxygenases (HO) catalyze the oxidative cleavage of heme to generate biliverdin, CO, and free iron. In humans, heme oxygenase-1 (hHO-1) is overexpressed in tumor tissues, where it helps to protect cancer cells from anticancer agents, while HOs in fungal pathogens, such as Candida albicans, funct...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857669/ https://ncbi.nlm.nih.gov/pubmed/19694439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9011258 |
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