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Isoporphyrin Intermediate in Heme Oxygenase Catalysis: OXIDATION OF α-MESO-PHENYLHEME
Human heme oxygenase-1 (hHO-1) catalyzes the O(2)- and NADPH-dependent oxidation of heme to biliverdin, CO, and free iron. The first step involves regiospecific insertion of an oxygen atom at the α-meso carbon by a ferric hydroperoxide and is predicted to proceed via an isoporphyrin π-cation interme...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Biochemistry and Molecular Biology
2008
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2443647/ https://ncbi.nlm.nih.gov/pubmed/18487208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709685200 |
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