Inhibition of Neddylation Represses Lipopolysaccharide-induced Proinflammatory Cytokine Production in Macrophage Cells

Cullin-RING E3 ligases (CRLs) are a class of ubiquitin ligases that control the proteasomal degradation of numerous target proteins, including IκB, and the activity of these CRLs are positively regulated by conjugation of a Nedd8 polypeptide onto Cullin proteins in a process called neddylation. CRL-...

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Main Authors: Chang, Fang-Mei, Reyna, Sara M., Granados, Jose C., Wei, Sung-Jen, Innis-Whitehouse, Wendy, Maffi, Shivani K., Rodriguez, Edward, Slaga, Thomas J., Short, John D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471689/
https://ncbi.nlm.nih.gov/pubmed/22927439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.397703
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