Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 alpha

Neutrophils are highly specialized innate immune effector cells that evolved for antimicrobial host defense. In response to inflammatory stimuli and pathogens, they form neutrophil extracellular traps (NETs), which capture and kill extracellular microbes. Deficient NET formation predisposes humans t...

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Autors principals: McInturff, Alison M., Cody, Mark J., Elliott, Elizabeth A., Glenn, Jared W., Rowley, Jesse W., Rondina, Matthew T., Yost, Christian C.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Phagocytes, Granulocytes, and Myelopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471519/
https://ncbi.nlm.nih.gov/pubmed/22919032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-405993
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