Kinetic measurement of 2-aminopurine X cytosine and 2-aminopurine X thymine base pairs as a test of DNA polymerase fidelity mechanisms.

Enzyme kinetic measurements are presented showing that Km rather than maximum velocity (Vmax) discrimination governs the frequency of forming 2-aminopurine X cytosine base mispairs by DNA polymerase alpha. An in vitro system is used in which incorporation of dTMP or dCMP occurs opposite a template 2...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Watanabe, S M, Goodman, M F
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1982
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC347139/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6959128/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.21.6429
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