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Hedgehog pathway inhibition and the race against tumor evolution
Dependence of basal cell carcinomas and medulloblastomas on the Hedgehog pathway provides an opportunity for targeted or “personalized” therapy. The recent effectiveness and FDA approval of the first Smoothened inhibitors validates this class of agents, but has revealed drug-resistant tumor variants...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Rockefeller University Press
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3471227/ https://ncbi.nlm.nih.gov/pubmed/23071148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201207140 |
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