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A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B
By phosphorylating Thr3 of histone H3, Haspin promotes centromeric recruitment of the chromosome passenger complex (CPC) during mitosis. Aurora B kinase, a CPC subunit, sustains chromosome bi-orientation and the spindle assembly checkpoint (SAC). Here, we characterize the small molecule 5-iodotuberc...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3471222/ https://ncbi.nlm.nih.gov/pubmed/23071153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201205119 |
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