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MRS2500 [2-Iodo-N(6)-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate], a Potent, Selective, and Stable Antagonist of the Platelet P2Y(1) Receptor with Strong Antithrombotic Activity in Mice

The platelet P2Y(1) ADP receptor is an attractive target for new antiplatelet drugs. However, because of the lack of strong and stable antagonists, only a few studies have suggested that pharmacological inhibition of the P2Y(1) receptor could efficiently inhibit experimental thrombosis in vivo. Our...

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Bibliografske podrobnosti
Main Authors: Hechler, Béatrice, Nonne, Christelle, Roh, Eun Joo, Cattaneo, Marco, Cazenave, Jean-Pierre, Lanza, François, Jacobson, Kenneth A., Gachet, Christian
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471153/
https://ncbi.nlm.nih.gov/pubmed/16236815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.105.094037
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