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MRS2500 [2-Iodo-N(6)-methyl-(N)-methanocarba-2′-deoxyadenosine-3′,5′-bisphosphate], a Potent, Selective, and Stable Antagonist of the Platelet P2Y(1) Receptor with Strong Antithrombotic Activity in Mice

The platelet P2Y(1) ADP receptor is an attractive target for new antiplatelet drugs. However, because of the lack of strong and stable antagonists, only a few studies have suggested that pharmacological inhibition of the P2Y(1) receptor could efficiently inhibit experimental thrombosis in vivo. Our...

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Detalhes bibliográficos
Main Authors: Hechler, Béatrice, Nonne, Christelle, Roh, Eun Joo, Cattaneo, Marco, Cazenave, Jean-Pierre, Lanza, François, Jacobson, Kenneth A., Gachet, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471153/
https://ncbi.nlm.nih.gov/pubmed/16236815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.105.094037
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