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More than insulator: multiple roles of CTCF at the H19-Igf2 imprinted domain

CTCF (CCCTC-binding factor)-mediated insulation at the H19-Insulin-like growth factor 2 (Igf2) imprinted domain is a classic example for imprinted gene regulation. DNA methylation difference in the imprinting control region (ICR) is inherited from the gametes and subsequently determines parental all...

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Bibliografiske detaljer
Main Authors: Singh, Purnima, Lee, Dong-Hoon, Szabó, Piroska E.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471092/
https://ncbi.nlm.nih.gov/pubmed/23087708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2012.00214
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