Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

Pyridoxal-5′-phosphate (vitamin B(6)) is an essential cofactor for many important enzymatic reactions such as transamination and decarboxylation. African trypanosomes are unable to synthesise vitamin B(6)de novo and rely on uptake of B(6) vitamers such as pyridoxal and pyridoxamine from their hosts,...

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Bibliographic Details
Main Authors: Jones, Deuan C, Alphey, Magnus S, Wyllie, Susan, Fairlamb, Alan H
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2012
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470933/
https://ncbi.nlm.nih.gov/pubmed/22857512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2012.08189.x
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