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Bleomycin in Octaarginine-modified Fusogenic Liposomes Results in Improved Tumor Growth Inhibition

Bleomycin (BLM) is an example of an anticancer drug that should be delivered into cytosol for its efficient therapeutic action. With this in mind, we developed octaarginine (R8)-modified fusogenic DOPE-liposomes (R8-DOPE-BLM). R8-modification dramatically increased (up to 50-fold) the cell-liposome...

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Détails bibliographiques
Auteurs principaux: Koshkaryev, Alexander, Piroyan, Aleksandr, Torchilin, Vladimir P.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470833/
https://ncbi.nlm.nih.gov/pubmed/22743614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2012.06.008
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