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Efficient feeding profile optimization for recombinant protein production using physiological information

A multivariate study was performed aiming at the optimization of a recombinant rhamnose inducible E. coli induction system with alkaline phosphatase as target product. The effects of typical factors with impact on post- as well as pre-induction feeding rates were investigated with respect to the spa...

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Autori principali: Wechselberger, Patrick, Sagmeister, Patrick, Engelking, Helge, Schmidt, Torsten, Wenger, Jana, Herwig, Christoph
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer-Verlag 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470689/
https://ncbi.nlm.nih.gov/pubmed/22740334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00449-012-0754-9
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