Effects of the Missense Mutations in Canine BRCA2 on BRC Repeat 3 Functions and Comparative Analyses between Canine and Human BRC Repeat 3

Mammary tumors are the most common tumor type in both human and canine females. Mutations in the breast cancer susceptibility gene, BRCA2, have been found in most cases of inherited human breast cancer. Similarly, the canine BRCA2 gene locus has been associated with mammary tumors in female dogs. Ho...

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Main Authors: Yoshikawa, Yasunaga, Ochiai, Kazuhiko, Morimatsu, Masami, Suzuki, Yu, Wada, Seiichi, Taoda, Takahiro, Iwai, Satomi, Chikazawa, Seishiro, Orino, Koichi, Watanabe, Kiyotaka
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470543/
https://ncbi.nlm.nih.gov/pubmed/23071527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045833
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