Identification of the core motif of the BRCA2 C-terminal RAD51-binding domain by comparing canine and human BRCA2

Mammary tumors are the most common tumors in women and non-spayed female dogs. One of the reasons for mammary tumors is mutations of the tumor suppressor gene, BRCA2. BRCA2 participates in homologous recombination repair by interacting with the RAD51 recombinase. BRCA2 has two RAD51-binding domains,...

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Bibliographische Detailangaben
Veröffentlicht in:J Vet Med Sci
Hauptverfasser: YOSHIKAWA, Yasunaga, MORIMATSU, Masami, OCHIAI, Kazuhiko, ISHIGURO-OONUMA, Toshina, MORIOKA, Ryo, OKUDA, Kento, ORINO, Koichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Japanese Society of Veterinary Science 2021
Schlagworte:
Biochemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8182314/
https://ncbi.nlm.nih.gov/pubmed/33731496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1292/jvms.21-0006
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