Mapping local structural perturbations in the native state of stefin B (cystatin B) under amyloid forming conditions

Unlike a number of amyloid-forming proteins, stefins, and in particular stefin B (cystatin B) form amyloids under conditions where the native state predominates. In order to trigger oligomerization processes, the stability of the protein needs to be compromised, favoring structural re-arrangement ho...

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Detalhes bibliográficos
Main Authors: Paramore, Robert, Morgan, Gareth J., Davis, Peter J., Sharma, Carrie-anne, Hounslow, Andrea, Taler-Verčič, Ajda, Žerovnik, Eva, Waltho, Jonathan P., Cliff, Matthew J., Staniforth, Rosemary A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2012
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469841/
https://ncbi.nlm.nih.gov/pubmed/23091450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2012.00094
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