Nanomolar ouabain increases NCX1 expression and enhances Ca(2+) signaling in human arterial myocytes: a mechanism that links salt to increased vascular resistance?

The mechanisms by which NaCl raises blood pressure (BP) in hypertension are unresolved, but much evidence indicates that endogenous ouabain is involved. In rodents, arterial smooth muscle cell (ASMC) Na(+) pumps with an α(2)-catalytic subunit (ouabain EC(50) ≤1.0 nM) are crucial for some hypertensio...

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Detaylı Bibliyografya
Asıl Yazarlar: Linde, Cristina I., Antos, Laura K., Golovina, Vera A., Blaustein, Mordecai P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2012
Konular:
Vascular Biology and Microcirculation
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469703/
https://ncbi.nlm.nih.gov/pubmed/22842068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00399.2012
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