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Nanomolar ouabain increases NCX1 expression and enhances Ca(2+) signaling in human arterial myocytes: a mechanism that links salt to increased vascular resistance?

The mechanisms by which NaCl raises blood pressure (BP) in hypertension are unresolved, but much evidence indicates that endogenous ouabain is involved. In rodents, arterial smooth muscle cell (ASMC) Na(+) pumps with an α(2)-catalytic subunit (ouabain EC(50) ≤1.0 nM) are crucial for some hypertensio...

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Detalhes bibliográficos
Main Authors: Linde, Cristina I., Antos, Laura K., Golovina, Vera A., Blaustein, Mordecai P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469703/
https://ncbi.nlm.nih.gov/pubmed/22842068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00399.2012
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