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Angiotensin II stimulates superoxide production in the thick ascending limb by activating NOX4

Angiotensin II (ANG II) stimulates production of superoxide (O(2)(−)) by NADPH oxidase (NOX) in medullary thick ascending limbs (TALs). There are three isoforms of the catalytic subunit (NOX1, 2, and 4) known to be expressed in the kidney. We hypothesized that NOX2 mediates ANG II-induced O(2)(−) pr...

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Hlavní autoři: Massey, Katherine J., Hong, Nancy J., Garvin, Jeffrey L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469600/
https://ncbi.nlm.nih.gov/pubmed/22875785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00457.2011
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