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Macrophages Sequester Clofazimine in an Intracellular Liquid Crystal-Like Supramolecular Organization
Clofazimine is a poorly-soluble but orally-bioavailable small molecule drug that massively accumulates in macrophages when administered over prolonged periods of time. To determine whether crystal-like drug inclusions (CLDIs) that form in subcellular spaces correspond to pure clofazimine crystals, m...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3469554/ https://ncbi.nlm.nih.gov/pubmed/23071814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047494 |
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