γ-Secretase inhibitors repress thymocyte development

A major therapeutic target in the search for a cure to the devastating Alzheimer's disease is γ-secretase. This activity resides in a multiprotein enzyme complex responsible for the generation of Aβ42 peptides, precipitates of which are thought to cause the disease. γ-Secretase is also a critic...

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Hlavní autoři: Hadland, Brandon K., Manley, Nancy R., Su, Dong-ming, Longmore, Gregory D., Moore, Chad L., Wolfe, Michael S., Schroeter, Eric H., Kopan, Raphael
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2001
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC34695/
https://ncbi.nlm.nih.gov/pubmed/11416218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.131202798
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