γ-Secretase inhibitors repress thymocyte development

A major therapeutic target in the search for a cure to the devastating Alzheimer's disease is γ-secretase. This activity resides in a multiprotein enzyme complex responsible for the generation of Aβ42 peptides, precipitates of which are thought to cause the disease. γ-Secretase is also a critical co...

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Εκδόθηκε σε:	Proc Natl Acad Sci U S A
Κύριοι συγγραφείς:	Hadland, Brandon K., Manley, Nancy R., Su, Dong-ming, Longmore, Gregory D., Moore, Chad L., Wolfe, Michael S., Schroeter, Eric H., Kopan, Raphael
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	National Academy of Sciences 2001
Θέματα:	Biological Sciences
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34695/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11416218/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.131202798
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