Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome

Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen and key regulator of both physiologic and pathologic (e.g., tumor) angiogenesis. In the course of studies designed to assess the ability of constitutive VEGF to block tumor regression in an inducible RAS melanoma model, m...

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Bibliographische Detailangaben
Hauptverfasser: Wong, Alex K., Alfert, Myra, Castrillon, Diego H., Shen, Qiong, Holash, Jocelyn, Yancopoulos, George D., Chin, Lynda
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC34694/
https://ncbi.nlm.nih.gov/pubmed/11404464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.121192298
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