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Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice
We cloned a rat vascular chymase (RVCH) from smooth muscle cells (SMCs) that converts angiotensin I to II and is up-regulated in SMC from spontaneously hypertensive vs. normotensive rats. To determine whether increased activity of RVCH is sufficient to cause hypertension, transgenic mice were genera...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The National Academy of Sciences
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC34692/ https://ncbi.nlm.nih.gov/pubmed/11416217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.131147598 |
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