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Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice
We cloned a rat vascular chymase (RVCH) from smooth muscle cells (SMCs) that converts angiotensin I to II and is up-regulated in SMC from spontaneously hypertensive vs. normotensive rats. To determine whether increased activity of RVCH is sufficient to cause hypertension, transgenic mice were genera...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The National Academy of Sciences
2001
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC34692/ https://ncbi.nlm.nih.gov/pubmed/11416217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.131147598 |
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