Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP

We have introduced a targeted mutation in SH2D1A/DSHP/SAP, the gene responsible for the human genetic disorder X-linked lymphoproliferative disease (XLP). SLAM-associated protein (SAP)-deficient mice had normal lymphocyte development, but on challenge with infectious agents, recapitulated features o...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Czar, Michael J., Kersh, Ellen N., Mijares, Lilia A., Lanier, Gibson, Lewis, Jennifer, Yap, George, Chen, Amy, Sher, Alan, Duckett, Colin S., Ahmed, Rafi, Schwartzberg, Pamela L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2001
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC34689/
https://ncbi.nlm.nih.gov/pubmed/11404475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.131193098
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky