Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models

The hepatocyte growth factor (HGF/SF) receptor, Met, regulates mitogenesis, motility, and morphogenesis in a cell type-dependent fashion. Activation of Met via autocrine, paracrine, or mutational mechanisms can lead to tumorigenesis and metastasis and numerous studies have linked inappropriate expre...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Cao, Brian, Su, Yanli, Oskarsson, Marianne, Zhao, Ping, Kort, Eric J., Fisher, Robert J., Wang, Ling-Mei, Vande Woude, George F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34688/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11416216/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.131200498
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