Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models

The hepatocyte growth factor (HGF/SF) receptor, Met, regulates mitogenesis, motility, and morphogenesis in a cell type-dependent fashion. Activation of Met via autocrine, paracrine, or mutational mechanisms can lead to tumorigenesis and metastasis and numerous studies have linked inappropriate expre...

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Detalhes bibliográficos
Main Authors: Cao, Brian, Su, Yanli, Oskarsson, Marianne, Zhao, Ping, Kort, Eric J., Fisher, Robert J., Wang, Ling-Mei, Vande Woude, George F.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC34688/
https://ncbi.nlm.nih.gov/pubmed/11416216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.131200498
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