The Effects of Amino Acid Composition of Glutamine-Rich Domains on Amyloid Formation and Fragmentation

Fragmentation of amyloid polymers by the chaperone Hsp104 allows them to propagate as prions in yeast. The factors which determine the frequency of fragmentation are unclear, though it is often presumed to depend on the physical strength of prion polymers. Proteins with long polyglutamine stretches...

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Main Authors: Alexandrov, Alexander I., Polyanskaya, Alla B., Serpionov, Genrikh V., Ter-Avanesyan, Michael D., Kushnirov, Vitaly V.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468588/
https://ncbi.nlm.nih.gov/pubmed/23071575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046458
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