Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts

Cardiac dysfunction is a primary cause of patient mortality in Duchenne muscular dystrophy, potentially related to elevated cytosolic calcium. However, the regional versus global functional consequences of cellular calcium mishandling have not been defined in the whole heart. Here we sought for the...

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Autores principales: Cheng, Ya-Jian, Lang, Di, Caruthers, Shelton D., Efimov, Igor R., Chen, Junjie, Wickline, Samuel A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2012
Materias:
Muscle Mechanics and Ventricular Function
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468475/
https://ncbi.nlm.nih.gov/pubmed/22777417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00321.2012
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