Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells

Intracellular signaling by the second messenger cyclic AMP (cAMP) activates the Ras-related small GTPase Rap1 through the guanine exchange factor Epac. This activation leads to effector protein interactions, activation, and biological responses in the vasculature, including vasorelaxation. In vascul...

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Auteurs principaux: Jeyaraj, Selvi C., Unger, Nicholas T., Eid, Ali H., Mitra, Srabani, Paul El-Dahdah, N., Quilliam, Lawrence A., Flavahan, Nicholas A., Chotani, Maqsood A.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2012
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468345/
https://ncbi.nlm.nih.gov/pubmed/22621783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00461.2011
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