Associations of serum sex steroid hormones and 5α-androstane-3α,17β-diol glucuronide concentrations with prostate cancer risk among men treated with finasteride

BACKGROUND: Finasteride, an inhibitor of 5 α-reductase (Type II), lowers intraprostatic dihydrotestosterone (DHT), which is reflected in serum as reduced 5α-androstane-3α,17β-diol glucuronide (3α-dG). It also modestly increases serum testosterone (T), estrone (E1) and estradiol (E2). In this altered...

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Hauptverfasser: Kristal, Alan R., Till, Cathee, Tangen, Catherine M., Goodman, Phyllis J., Neuhouser, Marian L., Stanczyk, Frank Z., Chu, Lisa W., Patel, Sherfaraz K., Thompson, Ian, Reichardt, Juergen K., Hoque, Ashraful, Platz, Elizabeth A., Figg, William D., Van Bokhoven, Adrie, Lippman, Scott M., Hsing, Ann W
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467348/
https://ncbi.nlm.nih.gov/pubmed/22879203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-12-0695
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