Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin

Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase the expression of agouti-related protein (AgRP) and neuropeptide Y (NPY) in...

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Hlavní autoři: Martins, Luís, Fernández-Mallo, Diana, Novelle, Marta G., Vázquez, María J., Tena-Sempere, Manuel, Nogueiras, Rubén, López, Miguel, Diéguez, Carlos
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467268/
https://ncbi.nlm.nih.gov/pubmed/23056530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046923
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