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Efficiency of Immunotoxin Cytotoxicity Is Modulated by the Intracellular Itinerary

Pseudomonas exotoxin-based immunotoxins, including LMB-2 (antiTac(F(v))-PE38), are proposed to traffic to the trans-Golgi network (TGN) and move by a retrograde pathway to the endoplasmic reticulum, where they undergo translocation to the cytoplasm, a step that is essential for cytotoxicity. The ret...

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Detalhes bibliográficos
Main Authors: Tortorella, Lori L., Pipalia, Nina H., Mukherjee, Sushmita, Pastan, Ira, Fitzgerald, David, Maxfield, Frederick R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467225/
https://ncbi.nlm.nih.gov/pubmed/23056628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047320
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