Thr 163 Phosphorylation Causes Mcl-1 Stabilization when Degradation Is Independent of the Adjacent GSK3-Targeted Phosphodegron, Promoting Drug Resistance in Cancer

The antiapoptotic Bcl-2 family member Mcl-1 is a PEST protein (containing sequences enriched in proline, glutamic acid, serine, and threonine) and is subject to rapid degradation via multiple pathways. Impaired degradation leading to the maintenance of Mcl-1 expression is an important determinant of...

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Detalhes bibliográficos
Main Authors: Nifoussi, Shanna K., Vrana, Julie A., Domina, Aaron M., De Biasio, Alfredo, Gui, Jingang, Gregory, Mark A., Hann, Stephen R., Craig, Ruth W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467206/
https://ncbi.nlm.nih.gov/pubmed/23056582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047060
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