Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome

BACKGROUND: Fragile X syndrome (FXS) is caused by the absence of the mRNA-binding protein Fragile X mental retardation protein (FMRP), encoded by the Fmr1 gene. Overactive signaling by group 1 metabotropic glutamate receptor (Grp1 mGluR) could contribute to slowed synaptic development and other symp...

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Detalhes bibliográficos
Main Authors: Xu, Zhao-Hui, Yang, Qi, Feng, Bin, Liu, Shui-bing, Zhang, Nan, Xing, Jiang-hao, Li, Xiao-Qiang, Wu, Yu-mei, Gao, Guo-Dong, Zhao, Ming-Gao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467183/
https://ncbi.nlm.nih.gov/pubmed/22640474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-24
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