Detection of DNA–protein crosslinks (DPCs) by novel direct fluorescence labeling methods: distinct stabilities of aldehyde and radiation-induced DPCs

Proteins are covalently trapped on DNA to form DNA–protein crosslinks (DPCs) when cells are exposed to DNA-damaging agents. DPCs interfere with many aspects of DNA transactions. The current DPC detection methods indirectly measure crosslinked proteins (CLPs) through DNA tethered to proteins. However...

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Bibliografske podrobnosti
Main Authors: Shoulkamy, Mahmoud I., Nakano, Toshiaki, Ohshima, Makiko, Hirayama, Ryoichi, Uzawa, Akiko, Furusawa, Yoshiya, Ide, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Methods Online
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467041/
https://ncbi.nlm.nih.gov/pubmed/22730301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks601
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