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A Hedgehog Survival Pathway in ‘Undead’ Lipotoxic Hepatocytes

BACKGROUND & AIMS: Ballooned hepatocytes in nonalcoholic steatohepatitis (NASH) generate sonic hedgehog (SHH). This observation is consistent with a cellular phenotype in which the cell death program has been initiated but cannot be executed. Our aim was to determine if ballooned hepatocytes hav...

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Detalhes bibliográficos
Main Authors: Kakisaka, Keisuke, Cazanave, Sophie C., Werneburg, Nathan W., Razumilava, Nataliya, Mertens, Joachim C., Bronk, Steve F., Gores, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467008/
https://ncbi.nlm.nih.gov/pubmed/22641094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2012.05.011
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