Myofibroblast-derived PDGF-BB Promotes Hedgehog Survival Signaling in Cholangiocarcinoma Cells

Cholangiocarcinoma (CCA) cells paradoxically express the death ligand TRAIL, and, therefore, are dependent upon potent survival signals to circumvent TRAIL cytotoxicity. CCAs are also highly desmoplastic cancers with a tumor microenvironment rich in myofibroblasts (MFBs). Herein, we examine a role f...

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Detalhes bibliográficos
Main Authors: Fingas, C D, Bronk, S F, Werneburg, N W, Mott, J L, Guicciardi, M E, Cazanave, S C, Mertens, J C, Sirica, A E, Gores, G J
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230714/
https://ncbi.nlm.nih.gov/pubmed/22038837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24588
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