A Single-Nucleotide Polymorphism in CYP2B6 Leads to >3-Fold Increases in Efavirenz Concentrations in Plasma and Hair Among HIV-Infected Women

Background. Efavirenz exhibits marked interindividual variability in plasma levels and toxicities. Prior pharmacogenetic studies usually measure exposure via single plasma levels, examine limited numbers of polymorphisms, and rarely model multiple contributors. We analyzed numerous genetic and nonge...

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Main Authors: Gandhi, Monica, Greenblatt, Ruth M., Bacchetti, Peter, Jin, Chengshi, Huang, Yong, Anastos, Kathryn, Cohen, Mardge, DeHovitz, Jack A., Sharp, Gerald B., Gange, Stephen J., Liu, Chenglong, Hanson, Susan C., Aouizerat, Bradley
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
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Major Articles and Brief Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466997/
https://ncbi.nlm.nih.gov/pubmed/22927450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis508
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