Underlying genetic structure impacts the association between CYP2B6 polymorphisms and response to efavirenz and nevirapine

OBJECTIVE: CYP2B6 variation predicts pharmacokinetic characteristics of its substrates. Consideration for underlying genetic structure is critical to protect against spurious associations with the highly polymorphic CYP2B6 gene. DESIGN: The effect of CYP2B6 variation on response to its substrates, n...

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Hoofdauteurs: Frasco, Melissa A., Mack, Wendy J., Van Den Berg, David, Aouizerat, Bradley E., Anastos, Kathryn, Cohen, Mardge, Dehovitz, Jack, Golub, Elizabeth T., Greenblatt, Ruth M., Liu, Chenglong, Conti, David V., Pearce, Celeste Leigh
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940150/
https://ncbi.nlm.nih.gov/pubmed/22951632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283593602
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